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The Agency for Healthcare Research and Quality (AHRQ) has released their Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: Annual Update #1, available for comment through April 15, 2022. The purpose of this update is to describe, evaluate and integrate newly identified evidence on benefits and harms of cannabinoids and similar plant-based substances (e.g., kratom) to treat chronic pain into the living review.